Miami Children’s Hospital Associate Professor of
Office: EC 2673
Phone: (305) 348-6112
Fax: (305) 348-6954
Biomedical Optics and Optical Spectroscopy
Dr. Lin’s research involves developing non-destructive optical and mechanical technologies that can detect disease development and tissue injuries in vivo. These techniques can be either one-dimensional (i.e., point detection) or multi-dimensional (i.e., imaging). The potential medical applications for such techniques, once developed, are abundant. For example, they may be used intraoperatively to guide tumor resection and to monitor the progression of a novel therapy.
Research related to neuroscience and neuroengineering
Dr. Lin’s research team at Miami Children’s Hospital is interested in developing new approaches to diagnose and treat pediatric epilepsy and brain tumor. Currently, their research efforts focus on addressing the intraoperative needs of pediatric brain tumor and epilepsy surgery. For example, the team has developing an effective surgical guidance system that can differentiate abnormal (i.e., neoplastic and epileptic) brain area from the normal one in vivo based on their intrinsic properties.
(a) A point detection system for intraoperative demarcation of pediatric neoplastic and epileptic brain. (b) A prototype imaging system for in vivo characterization of pediatric epileptic cortex.
Cortical vascularture study using optical imaging modalities. The vassel network is highlighted in the black/white picture.
Research related to cardiovascular diseases
Precise, timely delivery of adequate treatment for myocardial infarction (MI) is essential for both traditional treatments and developing therapeutic concepts such as cellular cardiomyogenesis. While many pathological and physiological alterations in the left ventricle (LV) myocardium have been identified post-infarction, on-site acquisition of this information remains unavailable in in vivo and intraoperative situations.
The long-term goal of this research project is to develop an effective technique, based on optical spectroscopy and fiber optics, in order to detect the pathophysiological changes in myocardium resulting from infarction in vivo. Once developed, this technique will be used in conjunction with cardiac catheterization to allow physicians (1) to identify viable myocardium within and around infarcts; (2) to gain specific knowledge regarding an infarct’s age and size; and (3) to assess microvascular damage surrounding infarcts.
Current Research Projects:
- Optical characterization of neoplastic and epileptogenic brain in pediatric patients
- In vivo differentiation of normal, stunned, hibernating, and scarred myocardium using optical spectroscopy
- Dynamics of tissue optical and mechanical properties
- Tissue viability assessment using optical spectroscopy
1. PC Chen, WC Lin, ‘A new algorithm for hemoglobin oxygen saturation determination from diffuse reflectance spectra,’ submitted to Physics in Medicine and Biology.
2. YL Ti, PC Chen, WC Lin, ‘In Vivo Assessment of Myocardial Tissue Injury and Remodeling Induced by Infarction Using Combined Optical Spectroscopy: Classification Algorithm Optimization,’ submitted to Technology in Cancer Research and Treatment.
3. S Oh, T Stewart, I Miller, S Bhatia, J Ragheb, M Duchowny, P Jayakar, WC Lin, In vivo diffuse reflectance spectroscopy of cortical tubers in children with tuberous sclerosis complex: a preliminary investigation, Epilepsia, accepted.
4. WC Lin, DI Sandberg, S Bhatia, M Johnson, S Oh, J Ragheb, ‘Diffuse reflectance spectroscopy for in vivo pediatric brain tumor detection’, Journal of Biomedical Optics, in press.
5. YL Ti, PC Chen, WC Lin, ‘In-vivo characterization of myocardial infarction using fluorescence and diffuse reflectance spectroscopy, Journal of Biomedical Optics, in press.
6. WC Lin, DI Sandberg, S Bhatia, M Johnson, G. Morrison, J Ragheb, “Optical spectroscopy for in vitro differentiation of pediatric neoplastic and epileptogenic brain lesions, ” J of Biomedical Optics, 2009 Jan-Feb;14(1):014028.
7. S Bhatia, WC Lin, S Oh, D Sandberg, J Ragheb, G Morrison, “Fluorescence and diffuse reflectance spectroscopy for intraoperative guidance in pediatric epilepsy surgery,” J Neurosurg Pediatrics. 2008 Apr; 1(4):A351.
8. Y Ti, WC Lin, “Effects of probe contact pressure on in vivo optical spectroscopy,” Optics Express, 2008 March; 16(6): 4250:4262.
9. SK Majumder, S Gebhart, MD Johnson, R Thompson, WC Lin, A Mahadevan-Jansen, “A probability-based spectroscopic diagnostic algorithm for simultaneous discrimination of brain tumor and tumor margins from normal brain tissue,” Applied Spectroscopy, 2007 May; 61(5):548-57.
10. DJ Parekh, WC Lin, SD Herrell, “In vivo assessment of radio frequency induced thermal damage of kidney using optical spectroscopy,” Journal of Urology, 2006 Oct;176(4):1626-1630.
11. SA Toms, P Konrad, WC Lin, RJ Weil, “Neuro-oncological applications of optical spectroscopy”, Technology in Cancer Research and Treatment, 2006 Jun; 5: 231 – 238.
12. S Gebhart, WC Lin, A Mahadevan-Jansen, “Normal and neoplastic brain tissue optical properties using inverse adding-doubling,” Physics in Medicine and Biology, 2006 Apr 21;51(8):2011-27.
13. DJ Parekh, WC Lin, SD Herrell, “Optical spectroscopy characteristics can differentiate benign and malignant renal tissues: A potentially useful modality,” Journal of Urology, 2005 Nov; 174(5):1754-8.
14. SA Toms, WC Lin, RJ Weil, MD Johnson, ED Jansen, A Mahadevan-Jansen, “Intraoperative Optical spectroscopy identifies infiltrating glioma margins with high sensitivity,” Neurosurgery, 2005 Oct;57(4 Suppl):382-91; discussion 382-91.
15. WC Lin, M Johnson, RJ Weil, A Mahadevan-Jansen, SA Toms, “In vivo optical spectroscopic detection of radiation injury in brain tissue,” Neurosurgery, 2005 Sep;57(3):518-25; discussion 518-25.
16. S Gebhart, A Mahadevan-Jansen, WC Lin, “Experimental and simulated angular profiles of fluorescence and diffuse reflectance emission from turbid media,” Applied Optics, 2005 Aug 10; 44(23):4884-901.
17. CD Anderson, WC Lin, JT Beckham, A Mahadevan-Jansen, CR Buttemere, MK Washington, DJ Phillips, J Pierce, IB Nicoud, CW Pinson, RS Chari, “Fluorescence spectroscopy accurately detects irreversible cell damage during hepatic radiofrequency ablation,” Surgery, 2004 Sep; 136; 524-531.
18. CD Anderson, WC Lin, CR Buttemere, MK Washington, A Mahadevan-Jansen, J Pierce, IB Nicoud, CW Pinson, and RS Chari, “Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation,” Journal of Gastrointestinal Surgery, 2004 Sep-Oct; 8: 660-669.
19. CR Buttemere, RS Chari, CD Anderson, MK Washington, A Mahadevan-Jansen, WC Lin, “In vivo assessment of thermal damage in the liver using optical spectroscopy,” Journal of Biomedical Optics, 2004 Sep-Oct; Vol. 9, No.5, p. 1018-1027.
20. WC Lin, CR Buttemere, A Mahadevan-Jansen, “Effects of thermal damage on the in vitro optical and fluorescence characteristics of liver tissues,” IEEE Journal of Selected Topics in Quantum Electronics, 2003 March, Vol. 9, No.2, p. 162-170.
21. PD O’Neal, GL Cote, M Motamedi, J Chen, WC Lin, “Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids,” Journal of Biomedical Optics, 2003 Jan; Vol. 8 No. 1. p. 33-39.
22. WC Lin, SA Toms, ED Jansen, A Mahadevan-Jansen, “Intraoperative application of optical spectroscopy in the presence of blood,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 7, No. 6, p. 996-1003, 2001.
23. WC Lin, SA Toms, M Johnson, ED Jansen, A Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochemistry and Photobiology, Vol. 73, No, 4, p. 396-402, 2001.
24. WC Lin, SA Toms, M Motamedi, ED Jansen, A Mahadevan-Jansen, “Brain tumor demarcation using optical spectroscopy; an in vitro study,” Journal of Biomedical Optics, Vol. 5, No. 2, p. 214-220, 2000.
25. WC Lin, M Motamedi, AJ Welch, “Dynamics of tissue optics during laser heating of turbid media,” Applied Optics, Vol. 35, No. 19, p. 3413-3420, 1996.
26. WC Lin, M Motamedi, AJ Welch, “Nonlinear optical behavior of ocular tissue during laser irradiation,” Applied Optics, Vol. 34, No. 34, p. 7979-7985, 1995.