Assistant Research Professor
Research Interests: Computational modeling, Cardiovascular system, Finite Element Analysis (FEA), Computational Fluid Dynamics (CFD), Fluid-Structure Interaction (FSI), Biomechanics, and Biotransport.Research Advancements: Dr. Mirza creates computational physiological models to study various diseases with a specialty in cardiovascular disorders.
Research Area: Research in Engineered Tissue Model Systems
Biography
Dr. Asad Mirza began his academic career in August 2014 as an undergraduate in the Department of Biomedical Engineering at Florida International University (FIU). He conducted undergraduate research as part of the Ronald E. McNair Post-Baccalaureate Achievement Program with Dr. Nikolaos Tsoukias working on multi-cell models, pericytes, and microvascular hemodynamic models. He attained his B.S. in Biomedical Engineering and was awarded the Outstanding Graduate Award in Biomedical Engineering in 2017. Dr. Mirza completed his Ph.D. in Biomedical Engineering in July 2024 at FIU under the advisement of Dr. Sharan Ramaswamy. He is also a recipient of the 2020-2021 Koerner Family Foundation Fellowship Award. In 2024, Dr. Mirza became an Assistant Research Professor in the Biomedical Engineering Department at FIU.
Dr. Mirza is passionate about both teaching and modeling the cardiovascular system to study valve diseases. His primary research focus has been on identifying computational fluid dynamics (CFD) derived biomarkers to predict early-stage calcific aortic valve disease (CAVD). He also spends time sharing his expertise with both students and colleagues in their work ranging from image processing, computer vision, drug transport, aortic/mitral valve modeling, physiological system development, CAD design, simulation advisement, 3D printing, and code debugging and optimization.
Selected Publications
1. Xiao, Z., Postma, R. J., van Zonneveld, A. J., van den Berg, B. M., Sol, W. M. P. J., White, N. A., van de Stadt, H. J. F., Mirza, A., Wen, J., Bijkerk, R., & Rotmans, J. I. (2024). A bypass flow model to study endothelial cell mechanotransduction across diverse flow environments. Materials Today Bio, 27, Article 101121. https://doi.org/10.1016/j.mtbio.2024.101121
2. Mirza, A., & Ramaswamy, S. (2022). Importance of Non-Newtonian Computational Fluid Modeling on Severely Calcified Aortic Valve Geometries-Insights from Quasi-Steady State Simulations. Journal of biomechanical engineering, 144(11), 114501. https://doi.org/10.1115/1.4054630
3. Gonzalez, B. A., Herrera, A., Ponce, C., Gonzalez Perez, M., Hsu, C. D., Mirza, A., Perez, M., & Ramaswamy, S. (2022). Stem Cell-Secreted Allogeneic Elastin-Rich Matrix with Subsequent Decellularization for the Treatment of Critical Valve Diseases in the Young. Bioengineering (Basel, Switzerland), 9(10), 587. https://doi.org/10.3390/bioengineering9100587
4. Gonzalez, B. A., Perez-Nevarez, M., Mirza, A., Perez, M. G., Lin, Y. M., Hsu, C. D., Caobi, A., Raymond, A., Gomez Hernandez, M. E., Fernandez-Lima, F., George, F., & Ramaswamy, S. (2020). Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype. Frontiers in cardiovascular medicine, 7, 69. https://doi.org/10.3389/fcvm.2020.00069
5. Mozneb, M., Mirza, A. M., & Li, C. Z. (2020). Non-Invasive Plasmonic-Based Real-Time Characterization of Cardiac Drugs on Cardiomyocytes Functional Behavior. Analytical chemistry, 92(2), 2244–2250. https://doi.org/10.1021/acs.analchem.9b04956
6. Mirza, A., Hsu, C. P. D., Matheny, R., & Ramaswamy, S. (2020). Hydrodynamic Assessment of a Small Intestinal Submucosa Tubular Mitral Valve. Structural Heart, 4(sup1), 114. https://doi.org/10.1080/24748706.2020.1717272
7. Tesfamariam, M. D., Mirza, A. M., Chaparro, D., Ali, A. Z., Montalvan, R., Saytashev, I., Gonzalez, B. A., Barreto, A., Ramella-Roman, J., Hutcheson, J. D., & Ramaswamy, S. (2019). Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure. Bioengineering (Basel, Switzerland), 6(2), 39. https://doi.org/10.3390/bioengineering6020039
8. Ashenagar, B., Moshkforoush, A., Mirza, A. and Tsoukias, N. (2019), Integrative Modeling of Functional Hyperemia: From Ion Channel Activity to Functional Imaging. The FASEB Journal, 33: 684.3-684.3. https://doi.org/10.1096/fasebj.2019.33.1_supplement.684.3
9. Mirza, A. M., Moshkforoush, A., Giles, W. R. and Tsoukias, N. (2018), A Mathematical Model of Plasma Membrane Electrophysiology of a Brain Capillary Pericyte: Investigating Pericyte Contribution to the Electrical Properties of the Capillary Network. The FASEB Journal, 32: 712.10-712.10. https://doi.org/10.1096/fasebj.2018.32.1_supplement.712.10