Damiano Angoli, Ph.D.
Research Assistant Professor
Research Interests: Biophysics of ion channels and transporters; Electrophysiology and imaging applied to cell/tissue physiology and drug discovery studies.Research Advancements: Translational and experimental medicine in particular for the study of neurovascular, cardiovascular and respiratory systems physiology.
Research Area: Applied Electrophysiological techniques for the study of the neurovascular coupling.
Lab: Vascular Physiology and Biotransport
Website: https://bme.fiu.edu/people/faculty-instructors/damiano-angoli-ph-d/
Biography
Dr. Damiano Angoli received his B.S and Master in Biology at University of Milan, Italy. He then spent 12 years in Canada to work at Simon Fraser University (5 years) and at University of British Columbia, working in the field of cardiovascular research. In 2013 he started his doctoral degree program in the new field of Translational and Experimental Medicine at University of Insubria, Italy, graduating in 2018. In his work, he applied the electrophysiological techniques learned in the previous years for drug discovery purpose and he collaborated with the private sector from 2019 to 2024 participating in the validation and patent acquisition of proprietary amino acid formulations for the enhancement of the treatments in patients with various dysfunctional epithelial (gut-lung axis).
Selected Publications
1. Sasidharan A, Grosche A, Xu X, Kinane TB, Angoli D, Vidyasagar S. Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells. PLoS One. 2024 Jul 25;19(7):e0307809. doi: 10.1371/journal.pone.0307809. eCollection 2024.
2. Angoli D, Geramipour A, Danziger ZC. Validation of an efficient and continuous urodynamic monitoring system for awake, unrestrained, chronic rodent studies. Am J Physiol Renal Physiol. 2020 Jan 1:318(1):F86-F95. Epub 2019 Nov 18.
3. Provence A, Angoli D, and Petkov GV. KV7 Channel Activation by the Novel Activator ML213: Role for Heteromeric KV7.4/KV7.5 Channels in Guinea Pig Detrusor Smooth Muscle Function. Journal of Pharmacology and Experimental Therapeutics October 30, 2017, jpet.117.243162; DOI: https://doi.org/10.1124/jpet.117.243162
4. Macri V, Angoli D, Accili EA. Architecture of the HCN selectivity filter and control of cation permeation. Sci Rep. 2012;2:894. Epub 2012 Nov 27.
5. Hegle AP, Nazzari H, Roth A, Angoli D, Accili EA. Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression. Am J Physiol Cell Physiol. 2010 May;298(5):C1066-76. Epub 2010 Feb 3.
6. Peters CJ, Chow SS, Angoli D, Nazzari H, Cayabyab FS, Morshedian A, Accili EA. In situ codistribution and functional interactions of SAP97 with sinoatrial isoforms of HCN channels. J Mol Cell Cardiol. 2009 May;46(5):636-43. Epub 2009 Jan 27.
7. Nazzari H, Angoli D, Chow SS, Whitaker G, Leclair L, McDonald E, Macri V, Zahynacz K, Walker V, Accili EA. Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain. Am J Physiol Cell Physiol. 2008 Sep;295(3):C642-52. Epub 2008 Jul 9.
8. Whitaker GM, Angoli D, Nazzari H, Shigemoto R, Accili EA. HCN2 and HCN4 isoforms selfassemble and co-assemble with equal preference to form functional pacemaker channels. J Biol Chem. 2007 Aug 3;282(31):22900-9. Epub 2007 Jun 6.
9. Macri V, Proenza C, Agranovich E, Angoli D, Accili EA. Separable gating mechanisms in a Mammalian pacemaker channel. J Biol Chem. 2002 Sep 27;277(39):35939-46.
10. Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA. Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarizationactivated, cyclic nucleotide-gated channels. J Biol Chem. 2002 Aug 16;277(33):29634-42.
11. Proenza C, Angoli D, Agranovich E, Macri V, Accili EA. Pacemaker channels produce an instantaneous current. J Biol Chem. 2002 Feb 15;277(7):5101-9
12. Angoli D, Corona P, Baresi R, Mora M, Wanke E. Laminin-alpha2 but not -alpha1-mediated adhesion of human (Duchenne) and murine (mdx) dystrophic myotubes is seriously defective. FEBS Lett. 1997 May 26;408(3):341-4.
13. Angoli D, Delia D, Wanke E. Early cytoplasmic acidification in retinamide-mediated apoptosis of human promyelocytic leukemia cells. Biochem Biophys Res Commun. 1996 Dec 13;229(2):681-5.