Dr. Ranu Jung
The research agenda of the Adaptive Neural Systems (ANS) Laboratory is at the intersection between bioengineering, neuroscience and rehabilitation. By applying a multifaceted approach, the laboratory investigates the effects of trauma and disorders of the nervous system to replace damaged or lost functionality or to repair the system using advanced adaptive devices and therapeutic techniques. Driven by the needs of potential users, the laboratory is designing and developing technology to offset the effects of limb amputation and spinal cord injury and understand its impact on nervous system function.
Dr. Zachary Danziger
Our Lab is developing computational and experimental tools to eavesdrop on the nervous system (called neural decoding) and give commands to the nervous system (through electrical stimulation). These decoding and stimulation techniques are used to help understand and treat neurological disorders. We are applying our methods to the neural control of the urinary tract and to direct brain control of computer systems.
Bioelectronic and Electronic Packaging Lab
Dr. Raj Markondeya
Current bioelectronic packaging approaches for neural stimulation and recording involve large enclosures with leads and connectors that are not scalable to address the need for high-channel density nerve interfaces in ultra-thin or flexible form-factors. A highly-miniaturized fully-implanted high-density electrode array that is actively powered on or close to the electrode array itself, with integrated data processing, can enable new applications and opportunities for healthcare. Realizing these systems require heterogeneous integration of several functions such as power transfer and conversion, data processing, high-density but biocompatible electrode-tissue interfaces and miniaturized hermetic packages. All these functions need to be achieved in sub-millimeter dimensions. The bioelectronic packaging group focuses on developing system components and integration solutions to realize such next-generation bioelectronic systems.
Dr. Wei-Chiang Lin
The mission of the Creative Lab is to produce creative engineering solutions for complex problems in biomedicine. Currently the team focuses on developing non-destructive optical and mechanical techniques that can detect disease development and tissue injuries in vivo. These techniques can be either one-dimensional (i.e., point detection) or multi-dimensional (i.e., imaging). The potential medical applications for such techniques, once developed, are abundant. For example, they may be used intraoperatively to guide tumor resection and to monitor the progression of a novel therapy.
Dr. Joshua Hutcheson
Research in the CMRL focuses on the mechanisms through which tissues are built, maintained, and remodeled. The primary thrust of the lab is on cardiovascular disease—the leading global cause of death. Researchers in the CMRL work at the interface of engineering and biology and study the mechanisms through which mechanical forces influence cell and tissue behavior. By understanding the ways that cells sense and respond to each other and to changes in their environment, the goal of the CMRL is to develop new ways to detect initiators of disease and find interventions that restore tissue to a normal state.
Dr. Anthony McGoron
Research focuses on image guided therapy of cancer using polymer and inorganic nanoparticles, microparticles and small molecules. Imaging is used to identify patients likely to respond to a particular therapy, to monitor the delivery of the drug and the patient’s response to the therapy, and to guide surgical resection of tumors. Molecular Imaging modalities include nuclear (PET and SPECT), near-infrared fluorescence, and Surface Enhanced Raman Spectroscopy (SERS). Therapeutic approaches include chemotherapy, photo-dynamic therapy, photo-thermal therapy, and radiation therapy.
Dr. Shuliang Jiao
The long term goal of the Eye Imaging Lab is research is to help prevent and cure blindness through technological innovations. Dr. Jiao’s lab, is dedicated to the development of novel optical technologies for 3D high resolution imaging of the anatomy and functions of the eye in vivo. The optical imaging technologies the lab currently focuses on include Optical Coherence Tomography (OCT), Photoacoustic Microscopy, and Multimodal Imaging. These technologies serve as tools for the research and diagnosis of diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. They also provide powerful tools for monitoring the functional regeneration of photoreceptors in regenerative medicine such as stem cell therapy.
Dr. Jessica Ramella-Roman
The Medical Photonics Laboratory (MPL) at FIU conducts research in bio-photonics and focuses particularly on the development of devices and methodologies for diagnosis of disease. The lab focuses on the detection of early signs of Diabetic Retinopathy, a disease associated with diabetes, using spectroscopic and polarimetric techniques. They are also developing methodologies for non-invasive monitoring of the skin. They are conducting research on the discrimination of melanoma, one of the most dangerous forms of skin cancer, and we are seeking insights into several forms of skin damage including pressure damage, thermal damage, and electrical damage.
Dr. Chenzhong Li
The research of our group interfaces with biomedical engineering, nanobiotechnology, electrochemistry, BioMEMS, biochemistry, nanomedicine, surface science, and materials science. The work done here looks ahead to the next generation of nanoelectrical components such as protein nanowires, DNA transistors as well as end use electronic devices such as Lab-on-Chip, biosensors and enzymatic biofuel cells.
Dr. Jorge Riera
The primary research interest of the Neuronal Mass Dynamics (NMD) laboratory is the development of methods for the integration of different brain imaging modalities. These methods will found direct translations into clinical practice, for instance in the diagnosis and intervention of a variety of brain disorders.
Dr. Anuradha Godavarty
The research done in the Optical Imaging Lab focuses in the area of optical-based molecular imaging (diffuse optical and fluorescence-enhanced optical imaging) and tomography. Optical imaging is based on the principles of near-infrared light propagation in scattering media (such as biological tissues) and the use of external fluorescent contrast agents to better differentiate normal and diseased tissues based on the differences in their optical properties. The research work requires an understanding of transport phenomena in biological systems, application of experimental skills towards instrument development, incorporation of optimization and mathematical tools towards image reconstructions, and development of biomedical aspects of engineering towards practical applications, such as cancer diagnostics, wound imaging, functional brain mapping.
Dr. Jacob McPherson
The PMRF lab studies interrelationships between motor control and pain processing in networks of spinal neurons. The ultimate goal of this work is to develop focused therapeutic strategies that facilitate and direct the intrinsic ability of the central nervous system to reorganize and repair following stroke or spinal cord injury. Our translational research draws from the fields of neurophysiology, neural engineering, neurology, and physical therapy, and incorporates both animal models and human-subjects experiments.
Dr. Sharan Ramaswamy
The Tissue Engineered Mechanics, Imaging and Materials (TEMIM) laboratory’s primary research focus lies in the area of cell and engineered tissue mechanics with application in cardiovascular regenerative medicine. The TEMIM lab, conducts both experimental and computational investigations in this area. A major goal of the lab is to develop functional tissue engineered heart valves (TEHVs) using 1) porcine small intestinal submucosa (PSIS) substrates and 2) mechanically regulate stem cells for the TEHV application as well as for (3) broader application in cardiovascular regenerative medicine. Concurrently the TEMIM lab is also working towards the elucidation of mechanobiological cellular and molecular mechanisms that are involved in the etiology of valve diseases, particularly aortic valve calcification. A specific project in this area involves (4) the delineation of mechanosensitive fluid and structural conditions of the aortic valve due to elastin remodeling that may serve as an early indicator of calcific aortic valve disease (CAVD). In addition, at the cellular level, the lab is interested in identifying the fluid-induced mechanobiological responses of valve endothelial cells in valve homeostasis and in the development of CAVD. The research in the TEMIM lab has been supported by the AHA, NSF, industry and academic funding sources.
Vascular Physiology and Biotransport Laboratory
Dr. Nikolaos Tsoukias
The main focus of the laboratory is on the mechanisms that regulate blood flow and pressure in the human body. The lab investigates the physiology of the microcirculation through the parallel development of theoretical and experimental models. Mathematical modeling guides experimentation and assist in data analysis while in vitro experimental studies provide important modeling parameters and promote further model development.
Dr. James Schummers
The research in the Visual Cortical Circuits Laboratory lies at the intersection of two fundamental questions about brain function: How is an external sensory stimulus encoded in the activity of brain cells in the cerebral cortex? How do astrocyte interactions with neurons contribute to information processing? To address these questions, the lab makes use of recent developments in non-linear microscopy, viral vector engineering and protein engineering to ask cutting-edge questions about the cellular basis of brain function. In particular, current studies apply two-photon imaging of genetically-encoded calcium indicators that have been targeted to specific brain cell types via viral vectors with specific serotypes and promoters to enable measurements of cellular and subcellular activity in both neurons and astrocytes. With these tools, we address questions about the spatial scale of visual stimulus representation within cortical neurons and astrocyte, and the temporal dynamics of brain activity that underlie visual perception. Ultimately, these studies will lay the groundwork for interventions to rescue vision in patients with compromised vision, or other neurological dysfunctions.