Lab web page: http://web.eng.fiu.edu/tsoukiasweb/
Keywords: Multiscale computational modeling of cardiovascular function, inter- and intracellular signaling, calcium dynamics, membrane electrophysiology
Dr. Kapela’s research focuses on developing detailed models of vascular tone regulation in health and disease. Vascular tone regulates blood flow and pressure in the body and is a complex process controlled by multiple signal transduction pathways. Mathematical and computational modeling assists in the system analysis and experimentation. Multiscale modeling integrates experimental data from endothelial and smooth muscle cells on calcium dynamics and membrane electrophysiology at subcellular and cellular levels to predict vascular reactivity at multicellular macroscale/tissue level. The models are then used to understand altered vasoreactivity in various forms of hypertension (e.g., hypertension associated with changes in channel expression) and to propose therapeutic strategies. The models are formulated as systems of ordinary and partial differential equations and implemented in Fortran, Matlab, JSIM, and COMSOL multiphysics software.
A. Kapela and N. M. Tsoukias, “Multi-Scale FEM Modeling of Vascular Tone: From Membrane Currents to Vessel Mechanics,” IEEE Trans Biomed Eng Letters, 2011.
A. Kapela, S. Nagaraja, and N. M. Tsoukias, “A mathematical model of vasoreactivity in rat mesenteric arterioles. II. Conducted vasoreactivity,” Am J Physiol Heart Circ Physiol, vol. 298, pp. H52-65, Jan 2010.
A. Kapela, A. Bezerianos, and N. M. Tsoukias, “A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communication,” Microcirculation, vol. 16, pp. 694-713, Nov 2009.
A. Kapela, A. Bezerianos, and N. M. Tsoukias, “A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: agonist and NO stimulation,” J Theor Biol, vol. 253, pp. 238-60, Jul 21 2008.
A. Kapela, N. Tsoukias, and A. Bezerianos, “New aspects of vulnerability in heterogeneous models of ventricular wall and its modulation by loss of cardiac sodium channel function,” Med Biol Eng Comput, vol. 43, pp. 387-94, May 2005.