Research Interests: Mechanisms of seizure generation, propagation, generalization and termination, Excitotoxic and metabolic abnormalities in the brain as a cause and/or consequence of seizures, Cellular and molecular processes involved in the neurobiology of sleep in health and disease and Calcium signaling in neurons and astrocytes in the context of excitatory and inhibitory transmission
Research Advancements: Oleksii Shandra has characterized a mouse model of post-traumatic epilepsy after repeated diffuse traumatic brain injury and a technique for live brain multi-photon imaging and single-cell laser stimulation to study astrocyte calcium signaling before and after brain injury. Dr. Shandra examines electrophysiological and imaging biomarkers of epileptogenesis and pathophysiological mechanisms of the astrocyte-neuron networks.
Research Area: Arrays and silicone probes, Live brain multi-photon microscopy, Preclinical models of traumatic brain injury, sleep deprivation and acquired epilepsy, Use of transgenic mice and adeno-associated viruses, Immunohistochemical assays and confocal microscopy, MATLAB-based algorithms for spike and seizure detection and power spectrum analysis, Drug screening, Deep brain stimulation, Transcranial magnetic brain stimulation
Lab: AHC 4, #507