Sharan Ramaswamy, Ph.D.
Phone: (305) 348-2532
Fax: (305) 348-6954
Lab: Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM)
Dr. Ramaswamy’s research interests lie primarily in the area of cell and engineered tissue mechanics with application in cardiovascular regenerative medicine. His laboratory, the “Tissue Engineered Mechanics, Imaging and Materials laboratory (TEMIM LAB)”, conducts both experimental and computational investigations in this area. Currently his major research goal is to integrate the various areas of his training into the differential mechano-regulation of stem cells towards the cardiovascular phenotype as well as the synthesis of viable engineered cardiovascular tissues, particularly, heart valves. This goal fragments into multiple areas of study that raises several scientific questions that he and his laboratory are trying to answer. These include: (1) tissue engineered heart valve replacement for critical congenital mitral and aortic valve disease, (2) leaflet repair using engineered heart valve tissues and (3) bioreactor development to create engineered cardiovascular tissue model systems to facilitate therapeutic discovery. Concurrently Dr. Ramaswamy is also working towards the elucidation of mechanobiological cellular and molecular mechanisms that are involved in the etiology of valve diseases (e.g. stenosis, calcification). His research is currently supported by the AHA and NSF. Dr. Ramaswamy is a Fellow of the American Heart Association and its Council on Basic Cardiovascular Sciences.
More information about Dr. Ramaswamy’s training can be found in his CV link above. More information concerning the TEMIM lab can be found by clicking the link below.
1) Rath S, Salinas M, Villegas A, Ramaswamy S. Differentiation and Distribution of Marrow Stem Cells in Flex-Flow Environments Demonstrate Support of the Valvular Phenotype. PLOS ONE, 2015 Nov 4;10(11):e0141802. doi: 10.1371/journal.pone.0141802.
2) Ramaswamy S, Boronyak SM, Le T, Holmes A, Sotiropoulos F, Sacks MS. A novel bioreactor for mechanobiological studies of engineered heart valve tissue formation under pulmonary arterial physiological flow conditions. J Biomech Eng. 2014 Dec;136(12):121009.
3) Salinas, M, Ramaswamy, S: Computational simulations predict a key role for oscillatory fluid shear stress in de novo valvular tissue formation. Journal of Biomechanics, 2014 Nov 47(14): 3517–3523.
4) Salinas M, Rath S, Villegas A, Unnikrishnan V, Ramaswamy S: Relative Effects of Fluid Oscillations and Nutrient Transport in the In Vitro Growth of Valvular Tissues, Cardiovascular Engineering and Technology, 2016 Jun;7(2):170-81. doi: 10.1007/s13239-016-0258-x. Epub 2016 Feb 8.
5) Rath S, Salinas M, Bhatacharjee S, Ramaswamy S. Marrow Stem Cell differentiation for Valvulogenesis via Oscillatory Flow and Nicotine Agonists: Unusual Suspects? Journal of Long Term Effects of Medical Implants 2015 25(1-2): 147-160.
6) Martinez C*, Henao A#, Rodriguez JE, Padgett KR, Ramaswamy S: Monitoring Steady Flow Effects on Cell Distribution in Engineered Valve Tissues by Magnetic Resonance Imaging. Mol Imaging. 2013 Oct;12
7) Alfonso A, Rafiee P, Rath S, Hernandez-Espino, Din M, George F, Ramaswamy S: Glycosaminoglycan Entrapment by Fibrin in Engineered Heart Valve Tissues. Acta Biomater. 2013 Sep; 9(9): 8149-57.
8) Ramaswamy S, Salinas M, Carrol R, Landaburo K, Ryans X, Crespo C, Rivero A, Al-Mousily F, DeGroff C, Bleiweis M, Yamaguchi H: Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves. J Vis Exp. 2013 Oct 17;(80):e50335. doi: 10.3791/50335.
9) Martinez C, Rath S, Van Gulden S, Pelaez D, Alfonso A, Fernandez N, Kos L, Cheung H, and Ramaswamy S: Periodontal Ligament Cells Cultured under Steady Flow Environments Demonstrate Potential for Use in Heart Valve Tissue Engineering. Tissue Eng Part A. 2013 Feb;19(3-4):458-66. doi: 10.1089/ten.TEA.2012.0149.
10) Salinas M, Schmidt DE, Libera M, Lange RR, Ramaswamy S: Oscillatory Shear Stress Created by Fluid Pulsatility Versus Flexed Specimen Configurations, Comput Methods Biomech Biomed Engin. 2014 May;17(7):728-39. Erratum in: Comput Methods Biomech Biomed Engin. 2014, 17(8): 932.