Research Advancements: Wei-Chiang Lin develops smart intraoperative guidance systems for surgery.
Research Area: Diagnostic Bioimaging Sensor Systems
Lab: Biomedical Engineering Creative Lab: W[CL]2
Dr. Wei-Chiang Lin is an Associate Professor of the Department of Biomedical Engineering at Florida International University, where he has been since 2004. He served as the interim chair of the Department from 2015 to 2017. Also, he is the co-director of the Orthotics and Prosthetics track, a self-supporting program within the Master’s Program in Biomedical Engineering. Dr. Lin obtained his B.S. degree in Biomedical Engineering from the Chung-Yuan Christian University in Taiwan, ROC in 1987. He received his M.S. and Ph.D. degrees in Biomedical Engineering from the University of Texas at Austin under the supervision of Dr. Ashley J. Welch and Dr. Massoud Motamedi. When he completed his Ph.D. degree in 1997, he received a postdoctoral fellowship from the W. M. Keck Foundation Free Electron Laser Center and joined the Department of Biomedical Engineering at Vanderbilt University in Nashville, TN, and he became a Research Assistant Professor in the Department in 2000. Dr. Lin’s research is focused on developing engineering solutions for diagnosing and treating tissue disorders and injuries, with a strong emphasis on pediatric brain disorders. To date, his research projects have been funded by the National Institute of Health, Department of Defense, Thrasher Research Fund, and American Heart Association.
Dr. Lin’s research involves developing non-destructive optical and mechanical technologies that can detect the development of disease and tissue injuries in vivo. These techniques can be either one-dimensional (i.e., point detection) or multi-dimensional (i.e., imaging). When such techniques have been developed and tested, there is significant potential for their use in many medical applications. For example, they may be used intraoperatively to guide tumor resection and to monitor the progression of novel therapies.
Current Research Projects
|Project Title||Description||Scientific and Engineering Disciplines Involved|
|Intraoperative Guidance System for Brain Tumor and Epilepsy Surgery||Develop an optical imaging system that performs intraoperative tissue differentiation and hence guides surgery||Biomedical Optics, Instrumentation, Signal Processing, Image Processing, Neurological Surgery|
|Development of Quantitative Optical Ultrasound System||Develop an all-optical ultrasound imaging system to quantify the acoustic/mechanical properties of biological tissues||Ultrasound Physics, Ultrasound Instrumentation, Photoacoustic Theory, Signal Processing, Imaging Processing, Materials Science|
|Wearable/Wireless Sensors for the Real-Time Acquisition of Physiological Signals and Analysis of Movements||Use various wearable and/or wireless sensors to monitor the physiological conditions and activities of the users in order to assess, for example, balance and energy expenditure.||Sensors, Wireless Communication, Physiology, Biomechanics, Biosignal Processing|
|Implantable CO2 Sensor||Develop implantable CO2 sensors to monitor regional CO2 production in vivo.||Sensors, Respiratory Physiology, Biosignal Processing, Biomedical Optics, Biomaterials|
|Digital Anatomy||Investigate microscopic network characteristics of a normal and a diseased cortex in 3-D using optical techniques||Microscopy, Signal Processing, Image Processing, 3D Modeling|
|Real-Time Optical Microdialysis||Develop optical spectroscopy techniques for real-time analysis of analytes from brain microdialysis||Biomedical Optics, Optical Spectroscopy, Brain Physiology|
- Yinchen Song, Sarahy Garcia, Yisel Frometa, Jessica C. Ramella-Roman, Mohammad Soltani, Mohamed Almadi, Jorge J Riera, Wei-Chiang Lin. “Quantitative assessment of hemodynamic and structural characteristics of in vivo brain tissue using total diffuse reflectance spectrum measured in a non-contact fashion”. Biomed. Opt. Express 8, 78-103 (2017).
- Yinchen Song, Jorge J Riera, Sanjiv Bhatia, John Ragheb, Claudia Garcia, Alexander G. Weil, Prasanna Jayakar, Wei-Chiang Lin. “Intraoperative optical mapping of epileptogenic cortices in pediatric patients”. NeuroImage: Clinical, 11, 423-434. 2016.
- Yinchen Song, Rafael A. Torres, Sarahy Garcia, Yisel Frometa, Jihye Bae, Abhay Deshmukh, Wei-Chiang Lin, Ying Zheng, Jorge J Riera. “Dysfunction of Neurovascular/Metabolic Coupling in Chronic Focal Epilepsy”. Biomedical Engineering, IEEE Transactions on 63(1):97-110. 2016.
- Yinchen Song, Basavaraju Sanganahalli, Fahmeed Hyder, Wei-Chiang Lin, Jorge J Riera. “Distributions of irritative zones are related to individual alterations of resting-state networks in focal epilepsy”. PLOS One 10(7): e0134352. 2015.
- Xizi Dai, Yen-Chih Huang, Jared Leichner, Madhvan Nair, Wei-Chiang Lin, Chen-Zhong Li. (2015) Peptide modified polymer poly (glycerol- dodecanedioate co-fumarate) for efficient control of motor neuron differentiation. Biomedical Materials (2015).
- Lin WD, Chang KP, Wang CH, Chen SJ, Fan PC, Weng WC, Lin WC, Tsai Y, Tsai CH, Chou IC, Tsai FJ, ‘Molecular Aspects of Dravet Syndrome Patients in Taiwan,’ Clinica Chimica Acta (2013).
- N Yadav, S Bhatia, J Ragheb, R Mehta, P Jayakar, W Yong , WC Lin, ‘In vivo detection of epileptic brain tissue using static fluorescence and diffuse reflectance spectroscopy,’ Biomed. Opt. 18(2), 027006 (Feb 05, 2013).
- Wang, C., C-YC Huang, and WC Lin. “Optical ATP biosensor for extracellular ATP measurement.” Biosensors and Bioelectronics 43: 355-361 (2013).