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Sharan Ramaswamy, Ph.D.

Dr. Sharan Ramaswamy, Associate Professor, Biomedical Engineering, Florida International University

Associate Professor

Download Curriculum VitaeResearch Interests: Cell and tissue mechanics with application in cardiovascular regenerative medicine
Research Advancements: Biomechanically-derived diagnostics and regenerative therapies for cardiovascular medicine.
Research Area: Engineered Tissue Model Systems
Lab: CV-PEUTICS - Cardiovascular Therapeutics Laboratory

Biography

Dr. Sharan Ramaswamy earned a PhD in Biomedical Engineering (BME) from the University of Iowa in 2003. Following a post-doctoral fellowship at the NIH and a research faculty position at the University of Pittsburgh, Dr. Ramaswamy joined the BME department at Florida International University (FIU) in December 2009 as an Assistant Professor. He is currently a tenured Associate Professor at FIU. His research expertise is in the areas of Cardiovascular Mechanobiology, Regenerative Medicine and Mechanics. He directs the Cardiovascular Therapeutics Laboratory’s (CV-PEUTICS Lab), (formerly known as the Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM Lab)) at FIU. He has numerous scientific articles published in his discipline in leading journals, proceedings and book chapters. His work has been funded by the American Heart Association (AHA), the Miami Heart Research Institute, the National Science Foundation, private industry and academia. He is a Fellow of the AHA and the American Society of Mechanical Engineers (ASME). Dr. Ramaswamy holds a patent in the area of bioreactors for cardiovascular regenerative medicine, a provisional patent in enhanced, stem cell-derived exosome production for the purposes of cardiac regeneration and is co-founder of a start-up company (DeNovo Biodevices LLC, Miami, FL). He is an advisor to several graduate and undergraduate students and participates in significant outreach mentorship efforts to schools in the Miami-Dade County Public School System.

Research

The Cardiovascular Therapeutics Laboratory (CV-PEUTICS LAB), formerly known as the TEMIM Lab’s primary research focus lies in the area of cell and engineered tissue mechanics with application in cardiovascular regenerative medicine. The CV-PEUTICS Lab, conducts both experimental and computational investigations in this area. A major goal of the lab is to develop functional valves with regenerative capacities (FVRC) using 1) porcine small intestinal submucosa (PSIS) substrates and 2) mechanically regulate stem cells for the FVRC application as well as for (3) broader application in cardiovascular regenerative medicine. Concurrently the CV-PEUTICS lab is also working towards the elucidation of mechanobiological cellular and molecular mechanisms that are involved in the etiology of valve diseases, particularly aortic valve calcification. Two specific projects in this area involve: (4) the delineation of flow conditions of the aortic valve that may serve to elucidate mechanosensitive pathways in vascular and valvular cells that lead to calcific aortic valve disease (CAVD), that in turn can be utilized for the development of an engineered CAVD tissue model system for drug discovery. (5) Computational biomechanical models that can help elucidate sub-clinical thrombosis (and stroke) risks in patient-specific geometries after undergoing a trans-aortic valve replacement (TAVR) procedure.
The research in the CV-PEUTICS Lab has been supported by the AHA, the Miami Heart Research Institute, NSF, industry and academic funding sources.

Selected Publications

1) Gonzalez BA, Pour Issa E, Mankame OV, Bustillos J, Cuellar A, Rodriguez AJ, Scholl F, Bibevski S, Hernandez L, Brehier V, Casares M, Rivas K, Morales P, Lopez J, Wagner J, Bibevski J, Agarwal A, George F, Ramaswamy S: Porcine small intestinal submucosa mitral valve material responses support acute somatic growth. Tissue Eng Part A. 2019 Dec 5. doi: 10.1089/ten.TEA.2019.0220.

 

2) Tesfamariam MD, Mirza AM, Chaparro D, Ali AZ, Montalvan R, Saytashev I, Gonzalez BA, Barreto A, Ramella-Roman J, Hutcheson JD, Ramaswamy S: Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure. Bioengineering (Basel). 2019 May 7;6(2). pii: E39. doi: 10.3390/bioengineering6020039, 2019.

 

3) Gonzalez B, Hernandez L, Bibevski S, Scholl F, Brehier V, Bibevski J, Rivas K, Morales P, Wagner J, Lopez J, Ramaswamy S: Recapitulation of Human Bio-scaffold Mitral Valve Growth in the Baboon Model. Circulation, 2018, Vol 138, No. Suppl_1, Abstract 11348.

 

4) Castellanos G, Nasim S, Medina DA, Rath S, Ramaswamy S: Stem Cell cytoskeletal responses to pulsatile flow in heart valve tissue engineering studies. Front. Cardiovasc. Med. 5:58. doi: 10.3389/fcvm.2018.00058, 2018.

 

 

5) Williams A, Nasim S, Salinas M, Moshkforoush A, Tsoukias N, Ramaswamy S: A “sweet-spot” for fluid-induced oscillations in the conditioning of stem cell-based engineered heart valve tissues. J Biomech. 2017 Dec 8;65:40-48. doi: 10.1016/j.jbiomech.2017.09.035. Epub 2017 Oct 7.
6) Mankame O, Valdes-Cruz L, Bibevski S, Scholl F, Baez I, Ramaswamy S: Early Hydrodynamic Assessment of a Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve for Mitral Valve Replacement. The Journal of the American College of Cardiology (JACC), 2017, March 69(11), Supplement: 590.

 

7) Ramaswamy S, Lordeus M, Mankame OV, Valdes-Cruz L, Bibevski S, Bell SM, Baez I, Scholl F. Hydrodynamic Assessment of Aortic Valves Prepared from Porcine Small Intestinal Submucosa. Cardiovasc Eng Technol. 2017, March; 8(1): 30-40.

 

8) Salinas M, Rath S, Villegas A, Unnikrishnan V, Ramaswamy S: Relative Effects of Fluid Oscillations and Nutrient Transport in the In Vitro Growth of Valvular Tissues, Cardiovascular Engineering and Technology, 2016 Jun;7(2):170-81. doi: 10.1007/s13239-016-0258-x. Epub 2016 Feb 8.

 

9) Rath S, Salinas M, Villegas A, Ramaswamy S. Differentiation and Distribution of Marrow Stem Cells in Flex-Flow Environments Demonstrate Support of the Valvular Phenotype. PLOS ONE, 2015 Nov 4;10(11):e0141802. doi: 10.1371/journal.pone.0141802.

 

 

10) Ramaswamy S, Boronyak SM, Le T, Holmes A, Sotiropoulos F, Sacks MS. A novel bioreactor for mechanobiological studies of engineered heart valve tissue formation under pulmonary arterial physiological flow conditions. J Biomech Eng. 2014 Dec;136(12):121009.
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